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Coronavirus modelers raise projected death toll

COVID-19 death projection
A chart created by the University of Washington’s Institute for Health Metrics and Evaluation traces the actual and projected trend line for daily COVID-19 deaths in the United States between March 1 and July 1, as solid and dotted lines respectively. The pink shaded area indicates a wide uncertainty interval for future death rates. (IHME Graphic)

The timeline has slipped to the right and the projected death toll has trended upward in a new projection from the creators of a closely watched computer model for the course of the U.S. coronavirus outbreak.

Tonight’s update from the University of Washington’s Institute for Health Metrics and Evaluation raises the outlook for the cumulative U.S. death toll through Aug. 4 from the 67,641 fatalities projected on April 22 to a new figure of 74,073.

That’s creeping closer to the death toll of 81,114 that IHME laid out in its first projection, way back in late March. Since then, the figures have gone as high as 93,000 and as low as 60,000.

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UW to conduct clinical trial for hydroxychloroquine

The University of Washington School of Medicine is looking for people who have tested positive for COVID-19 to participate in a clinical trial aimed at finding out whether a controversial drug called hydroxychloroquine can keep them from having to be hospitalized.

Word of UW Medicine’s clinical trial comes after reports about a study at Veterans Health Administration medical centers in which COVID-19 patients who took hydroxychloroquine, which is typically used to treat malaria and autoimmune disease, died at higher rates than those who didn’t take the drug.

Today, the Food and Drug Administration warned that hydroxychloroquine carries “known risks” of potentially deadly heart complications — and said the drug should be used in supervised settings such as clinical trials, where the risks can be better studied and mitigated.

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UW calls a halt to use of questionable test kits

Sample collection kits
Collection kits were made by Lingen Precision Medical Products in Shanghai. (Lingen Photo via Alibaba)

The University of Washington School of Medicine has alerted Seattle-King County public health officials and other partners to stop using a donated supply of specimen collection kits for coronavirus testing, due to quality control concerns.

In response, the Washington State Department of Health issued a recall order for about 12,000 of the Chinese-made kits, which were sent to local health jurisdictions, tribal nations and its partners across the state.

Concerns were raised on April 17 after UW Medicine determined that some of the kits, which were airlifted from Shanghai a couple of weeks ago with logistical assistance from Amazon, showed signs of contamination.

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How much longer should COVID-19 shutdowns last?

Reopening map
A color-coded map from the University of Washington’s Institute for Health Metrics and Evaluation shows when states are projected to reach thresholds for easing social distancing restrictions. (IHME Graphic)

The University of Washington epidemiologists who set up a widely watched model projecting the future course of the coronavirus outbreak have translated those projections into suggested time frames for loosening strict shelter-at-home orders across the country.

For Washington state, that time frame is the week of May 18, which is two weeks longer than the current expiration date for Gov. Jay Inslee’s “Stay Home, Stay Healthy” order.

Based on the current projections from UW’s Institute for Health Metrics and Evaluation, four states — Montana, Vermont, West Virginia and Hawaii — could loosen their restrictions as early as the week of May 4. Other states, ranging from Massachusetts and North Dakota to Arizona, may have to wait until the week of June 8 or later.

Those projected dates could shift, of course, depending on how the institute tweaks its models, which it’s done repeatedly over the past month. And in the end, it’s up to the nation’s governors, not researchers, to determine how strict their social distancing policies are.

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UW ramps up for ‘fantastic’ COVID-19 antibody test

Blood test in lab
Greg Pepper, manager of the UW Medicine Virology Lab, works on a diagnostic blood test designed to detect COVID-19 antibodies. (UW Medicine Photo)

The University of Washington School of Medicine’s Virology Lab is reporting encouraging results from trial runs of a new test from Abbott Laboratories that detects the antibodies created by people who have had COVID-19, whether they knew they had it or not.

“This is a really fantastic test,” Keith Jerome, who leads UW Medicine’s virology program, told reporters today. He said UW’s lab could process 4,000 samples per day starting next week, and conceivably ramp up to 14,000 samples per day within a couple of weeks.

The test will be made available through health care providers, in medical clinics or perhaps through workplaces. It analyzes blood that’s drawn from patients, and looks for the telltale antibodies that a body’s immune system creates to defend against the coronavirus known as SARS-CoV-2.

Epidemiologists say knowing who has had the virus will be key to tracking the true spread of COVID-19, and giving assurances to people who are returning to school and work — particularly in front-line jobs ranging from first responders and health care workers to grocery store clerks.

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Study focuses on tips for coping with COVID-19

An artist’s conception shows microscopic coronavirus particles. (CDC Illustration)

Can a daily dose of tips sent to your smartphone help you stay sane during a pandemic? That’s what a study planned by the University of Washington’s Center for the Science of Social Connection and SurveySignal aims to find out.

The UW center’s director, psychologist Jonathan Kanter, said the call for volunteers went out last week. As of today, nearly 1,000 people have enrolled — but there’s still a chance to get involved.

“We are hoping for 2,000,” Kanter told GeekWire in an email. “We will continue to enroll until we are full, which probably will be in a week or so.”

Study participants will be asked to take a short survey on their smartphone, every evening for four weeks. The survey will serve as a quick self-check of each person’s mood, social well-being and health.

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UW Medicine to test all patients for coronavirus

UW Medicine hospital room
UW Medicine says it’s taking measures to ensure that health care workers can safely care for hospital patients amid the coronavirus pandemic. (UW Medicine via YouTube)

The University of Washington’s medical system says it’s begun testing all patients admitted to its hospitals for coronavirus.

The change in policy recognizes the fact that some patients may carry the virus that causes COVID-19 even if they don’t have the best-known symptoms of the disease, such as fever or a dry cough.

“We are finding people who are asymptomatic who have COVID in their nasopharynx when we swab them,” Chloe Bryson-Cahn, an assistant professor of medicine at the University of Washington School of Medicine, said in a video about the policy change.

UW Medicine spokeswoman Susan Gregg said the previous policy was to test only patients who were being admitted with COVID-19 symptoms. “Now we will be testing all patients admitted to the hospitals even if they do not have symptoms,” she told GeekWire in an email. “This is similar to some of our surveillance activities to see who may be colonized with a particular resistant bacteria.”

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UW seeks 25,000 volunteers to try outbreak app

Coronavirus app
Smartphone app
All that’s needed to participate in the HIPPOCRATIC experiment is an Android or Apple smartphone with an internet connection. (UW Medicine via YouTube)

Can a smartphone app generate an early warning for an outbreak of coronavirus, flu, colds or other infections? A project funded by the Pentagon with an assist from the University of Washington aims to find out.

UW Medicine is recruiting 25,000 people nationwide for an app-based experiment called HIPPOCRATIC (which stands for Health and Injury Prediction and Prevention Using Complex Reasoning and Analytic Techniques Integrated on a Cellphone App … with a bit of poetic license.).

The app is funded by the Defense Advanced Research Projects Agency, which serves as the Pentagon’s technological think tank.

If the app does what researchers hope, it could provide data for quicker medical diagnoses, and keep people who are ill from returning to school, work or military duty too soon.

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UW Medicine kicks off $50M COVID-19 campaign

COVID-19 testing
A nurse prepares to screen a patient for coronavirus at a drive-through testing station at UW Medical Center – Northwest. (UW Medicine Photo / Randy Carnell)

The CEOs of Amazon and Microsoft are among thousands of people contributing to cover the $50 million in private support that the University of Washington School of Medicine expects to need to cope with the coronavirus outbreak.

So far, more than $20 million in contributions to the UW Medicine Emergency Response Fund have come in from about 3,400 donors, UW Medicine said today.

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Protein puzzle game finds 99 ways to beat virus

Protein structure
This is one of the high-scoring protein designs that will be turned into an actual protein binder for testing as an coronavirus-blocking agent. (Stomjoh via Foldit / UW Institute for Protein Design)

Who would have thought a video game could identify potential treatments for COVID-19? Researchers at the University of Washington’s Institute for Protein Design certainly thought so, and so far the game has produced 99 chances to win.

The game is a protein-folding puzzler called Foldit, which was created at UW’s Center for Game Science more than a decade ago and has attracted nearly more than 750,000 registered players since then.

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