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Big project aims to build a bit of a virtual brain

Image: Neuron network
This image shows a network of neurons reconstructed with large-scale electron microscopy. (Credit: Clay Reid, Allen Institute / Wei-Chung Lee, Harvard Medical School / Sam Ingersoll)

Seattle’s Allen Institute for Brain Science is in on a multimillion-dollar campaign to trace the connections between the neurons in a mouse’s brain and figure out what they do, well enough to create a 3-D wiring diagram.

The five-year project – backed by the federal government’s Intelligence Advanced Research Projects Activity, or IARPA – is aimed at reverse-engineering the way the brain processes information. The project is called Machine Intelligence From Cortical Networks, or MICRONS.

“The reason IARPA is funding this is not merely to get a better understanding of the brain, but to get inspiration from biology to do the next iteration of machine learning,” R. Clay Reid, the Allen Institute’s principal investigator for the project, told GeekWire.

IARPA is the U.S. intelligence community’s equivalent of the Pentagon’s DARPA think tank, and you can assume that the new types of artificial intelligence programs inspired by MICrONS could help give the United States an edge when it comes to analyzing data for national security purposes.

At the same time, neuroscientists will benefit from seeing how neurons work together in unprecedented detail. “It’s absolutely a win-win situation,” Reid said.

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Scientists list brain’s common gene patterns

Image: Brain gene expression
An image from the Allen Brain Explorer shows gene expression across the human brain. (Credit: Allen Institute for Brain Science)

Researchers say they’ve traced 32 of the most common genetic patterns at work in the human brain, as part of a mapping project that could lead to new insights about Alzheimer’s and other diseases.

“We’re really trying to understand the genetic basis for the architecture of the human brain,” said Ed Lein, a researcher at the Allen Institute for Brain Science and one of the authors of a study published online on Monday by Nature Neuroscience.

Lein told GeekWire that the study, based on data from the Allen Human Brain Atlas, demonstrates “we’re really much more similar than we are dissimilar” when it comes to the genetic code for our brain’s wiring. The genes that are most consistently associated with specific regions of the brain include some associated with Alzheimer’s, Parkinson’s and Huntington’s disease, as well as epilepsy and disorders associated with cocaine and nicotine use.

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