The Allen Institute’s HQ is in Seattle’s South Lake Union neighborhood. (GeekWire Photo / Kurt Schlosser)
Twenty years after Microsoft co-founder Paul Allen created the bioscience research center that bears his name, Seattle’s Allen Institute is still pushing out into new frontiers.
But this weekend, the nonprofit institute — and its hometown — are taking a little time to celebrate.
All this week, the Allen Institute has been highlighting Open Science Week, which touches upon one of the core values that Allen had in mind when he launched the institute with a $100 million donation on Sept. 16, 2003. And Seattle Mayor Bruce Harrell is giving the festivities an extra boost by issuing a proclamation designating Sept. 16 as “Open Science Day” in the Emerald City.
Neuroscientist Christof Koch rides on a Washington state ferry during a scene from "Aware: Glimpses of Consciousness." (Umbrella Films)
Could magic mushrooms hold the key that unlocks the secrets of consciousness?
Well, maybe not the only key. But Allen Institute neuroscientist Christof Koch says that hallucinogenic drugs such as psilocybin, the active ingredient found in special types of mushrooms, can contribute to clinical research into the roots of depression, ecstasy and what lies beneath our sense of self.
“What they can teach us about consciousness is that the self is just one aspect of consciousness,” Koch says in the latest episode of the Fiction Science podcast. “You’re still highly conscious, and very often this is associated with states of ecstasy, or states of fear or terror, or a combination of ecstasy and terror. … What’s remarkable is that in all of these states, the self is gone, and very often the external world is gone, yet you’re highly conscious.”
The quest to understand consciousness through detailed analysis of the brain’s structure and function, scientific studies of religious and traditional practices — and yes, research into the effects of psychedelic drugs — is the focus of a 102-minute documentary film titled “Aware: Glimpses of Consciousness.”
A color-coded 3-D reconstruction of cells from the MICrONS data set reveals complexity in a mouse brain. (MICrONS / Allen Institute)
Neuroscientists from Seattle’s Allen Institute and other research institutions have wrapped up a five-year, multimillion-dollar project with the release of a high-resolution 3-D map showing the connections between 200,000 cells in a clump of mouse brain about as big as a grain of sand.
MICrONS is meant to clear the way for reverse-engineering the structure of the brain to help computer scientists develop more human-like machine learning systems, but the database is likely to benefit biomedical researchers as well.
“We’re basically treating the brain circuit as a computer, and we asked three questions: What does it do? How is it wired up? What is the program?” R. Clay Reid, senior investigator at the Allen Institute and one of MICrONS’ lead scientists, said today in a news release. “Experiments were done to literally see the neurons’ activity, to watch them compute.”
An ancient city once known as "The Rise of Aten" has been unearthed in Luxor. (Egyptian Ministry of Tourism and Antiquities)
Egyptian archaeologists unearth a 3,000-year-old lost city, magnetic readings from muons could lead to new physics, and Elon Musk’s Neuralink venture has monkeys playing video games with neural impulses. Get the details on the Web:
The city was at one time called “The Rise of Aten,” reflecting the religious shift brought about by Akhenaten. Today it’s being called the “Lost Golden City.” During the past seven months of excavation, several neighborhoods have been uncovered, but the administrative and residential district hasn’t yet been brought forth from the sands. “The discovery of this lost city is the second most important archaeological discovery since the tomb of Tutankhamun,” said Betsy Bryan, an Egyptologist at Johns Hopkins University.
Anomalous results from a Fermilab experiment have added to the suspicion that scientists have finally found a flaw in one of their most successful theories, the Standard Model of particle physics. The anomalies have to do with the strength of the magnetic field for a weightier cousin of the electron, known as the muon. Data from Fermilab’s Muon g-2 experiment supported previous findings from Brookhaven National Laboratory that the muon’s magnetism is ever-so-slightly stronger than predicted by the Standard Model — just 2.5 parts per billion stronger.
If the results hold up, physicists might have to consider far-out explanations — for example, the existence of scads of particles that haven’t yet been detected, or a totally new take on the foundations of physics. But the findings will require further confirmation. Grand discoveries, like 2012’s detection of the Higgs boson, typically have to be confirmed to a confidence level of 5-sigma. Now the muon findings have hit 4.2-sigma — which doubters would say is still substandard.
In a Twitter exchange, Musk said human trials of the mind-reading system would begin, “hopefully, later this year.” He said Neuralink’s first brain-implant product would enable someone with paralysis to use a smartphone with their mind faster than someone using thumbs. “Later versions will be able to shunt signals from Neuralinks in brain to Neuralinks in body motor/sensory neuron clusters, thus enabling, for example, paraplegics to walk again,” Musk tweeted.
Neuralink co-founder Elon Musk holds a brain implant device between his fingers. (Neuralink via YouTube)
With grudging assistance from a trio of pigs, Neuralink co-founder Elon Musk showed off the startup’s state-of-the-art neuron-reading brain implant and announced that the system has received the Food and Drug Administration’s preliminary blessing as an experimental medical device.
During today’s demonstration at Neuralink’s headquarters in Fremont, Calif., it took a few minutes for wranglers to get the swine into their proper positions for what Musk called his “Three Little Pigs demonstration.”
One of the pigs was in her natural state, and roamed unremarkably around her straw-covered pen. Musk said the second pig had been given a brain implant that was later removed, showing that the operation could be reversed safely.
After some difficulty, a third pig named Gertrude was brought into her pen. As she rooted around in the straw, a sequence of jazzy electronic beeps played through the sound system. Musk said the tones were sounded whenever nerves in the pig’s snout triggered electrical impulses that were picked up by her brain implant.
“The beeps you’re hearing are real-time signals from the Neuralink in Gertrude’s head,” he said.
Eventually, Neuralink’s team plans to place the implants in people, initially to see if those who have become paralyzed due to spinal cord injuries can regain motor functions through thought alone.
Musk said the implant received a Breakthrough Device designation from the FDA last month. That doesn’t yet clear the way for human clinical trials, but it does put Neuralink on the fast track for consultation with the FDA’s experts during preparations for such trials.
Neuralink has received more than $150 million in funding, with roughly two-thirds of that support coming from Musk himself. Today he said the venture had about 100 employees. He expects that number to grow. “Over time, there might be 10,000 or more people at Neuralink,” he said.
This image shows a section of one hemisphere of a healthy brain from an older person at left,and a brain with advanced Alzheimer’s disease at right. (UW Medicine Photo)
A $40.5 million collaborative research center headquartered at Seattle’s Allen Institute aims to create high-resolution maps of brains ravaged by Alzheimer’s disease, to trace new paths to early diagnosis and treatment.
The center will draw upon expertise not only at the institute, but also at UW Medicine and Kaiser Permanente Washington Health Research Institute. Funding for the next five years comes from the National Institute on Aging, part of the National Institutes of Health.
Previous versions of the atlas were rendered with lower-resolution 3-D maps. The latest high-resolution maps are fine enough to pinpoint the locations of individual brain cells — which is crucial for interpreting datasets that contain thousands or millions of pieces of information.
“In the old days, people would define different regions of the brain by eye. As we get more and more data, that manual curation doesn’t scale anymore,” Lydia Ng, senior director of technology at the Seattle-based Allen Institute for Brain Science, explained in a news release. “Just as we have a reference genome sequence, you need a reference anatomy.”
A sculpture titled “MIRALL” stands sentry at the Allen Institute’s headquarters in Seattle’s South Lake Union district. (GeekWire Photo / Kurt Schlosser)
Seattle’s Allen Institute is heading into a new phase of research into neuroscience — a phase that includes reorganizing its current activities as well as adding new ones.
The Allen Institute for Brain Science, which is the largest division under the institute’s umbrella, was established by Microsoft co-founder Paul Allen in 2003 and has continued on its mission since Allen’s death in 2018. It’s grown to more than 300 scientists and staff members who work in two broad research areas.
One program, known as Cell Types, focuses on mapping out a “periodic table” of brain cells. The Allen Institute’s new 16-year plan calls for the Allen Institute for Brain Science to focus solely on studying brain cell types and neural connectivity.
The second program, known as MindScope, seeks to understand how the brain’s neural circuits produce the sense of vision. That field of study, along with the Allen Brain Observatory, will transition out of the Allen Institute for Brain Science to become a separate program at the Allen Institute.
A new division, due for launch in 2022, will focus on research related to neural computation and dynamics.
The Allen Institute’s Jerome Lecoq, one of the lead authors of a mouse-brain study, works on one of the 2-photon microscopes that was used to record neural activity in more than 200 mice. (Allen Institute Photo)
For years, neuroscientists have been monitoring the brain activity of mice as they looked at a wide range of images — including the film-noir classic “Touch of Evil” — in hopes of discovering deep insights about the workings of the visual system. Now they’ve come upon a plot twist worthy of director Orson Welles himself.
The latest results, reported today in the journal Nature Neuroscience by researchers at Seattle’s Allen Institute for Brain Science and at the University of Washington, suggest that more than 90% of the neurons in the visual cortex don’t work the way scientists thought.
“We thought that there are simple principles according to which these neurons process visual information, and those principles are all in the textbooks,” Christof Koch, the brain institute’s chief scientist and president, said in a news release. ”But now that we can survey tens of thousands of cells at once, we get a more subtle — and much more complicated picture.”
Not that there’s anything wrong with that.
“To me, that’s the business. In some sense, that’s the exciting thing,” Michael Buice, an associate investigator at the Allen Institute and one of the study’s lead authors, told GeekWire. “We’re in a more interesting place than we thought.”
