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Allen Frontiers Group awards $10M for neuroimmunology

The Paul G. Allen Frontiers Group, a division of the Seattle-based Allen Institute, is launching a research center in New York to focus on interactions between the nervous system and the immune system.

The Allen Discovery Center for Neuroimmune Interactions, headquartered at the Icahn School of Medicine at Mount Sinai, will receive $10 million over the course of four years from the Paul G. Allen Family Foundation, with a total potential for $20 million over eight years.

The award is the result of an open call for research proposals exploring fundamental questions at the intersection of neuroscience and immunology. It’s the latest open-science initiative celebrating the legacy of Microsoft co-founder Paul Allen, who died five years ago at the age of 65 from complications of non-Hodgkin’s lymphoma.

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Brain-cell atlases point to paths for future research

In a tour de force for neuroscience, teams of researchers have published a voluminous set of brain-cell atlases for humans and other primates.

The atlases are detailed in 21 research papers appearing in ScienceScience Advances and Science Translational Medicine — and could point scientists toward new strategies for addressing mental conditions ranging from Alzheimer’s disease and schizophrenia to epilepsy and ADHD.

“We need to understand the specifics of the human brain if we hope to understand human diseases,” Ed Lein, a senior investigator at Seattle’s Allen Institute, said in comments provided via video.

“Most of disease research tries to create a replicate or a model of a human disease in a species that doesn’t get that disease,” Lein explained. “But if we want to understand why we get it, and what the consequences are, and how one should treat it, we need to have a deep understanding of the human brain itself.”

The studies in the package released today are part of the National Institutes of Health’s BRAIN Initiative Cell Census Network, or BICCN, a program that was launched in 2017. The Allen Institute for Brain Science has played a major role in sharing data produced by the program.

One study analyzed more than a million cells taken from 42 regions of the brain. Another study drew high-quality samples from more than 100 brain regions. Yet another study focused on samples from prenatal brain tissue. The collective efforts of the research teams characterized more than 3,000 human brain cell types.

The researchers didn’t just examine the brain cells themselves. They also ran them through DNA analysis to learn which genes appeared to be linked to the cells’ functions and dysfunctions.

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Allen Institute hits 20 years on the open science frontier

Twenty years after Microsoft co-founder Paul Allen created the bioscience research center that bears his name, Seattle’s Allen Institute is still pushing out into new frontiers.

But this weekend, the nonprofit institute — and its hometown — are taking a little time to celebrate.

All this week, the Allen Institute has been highlighting Open Science Week, which touches upon one of the core values that Allen had in mind when he launched the institute with a $100 million donation on Sept. 16, 2003. And Seattle Mayor Bruce Harrell is giving the festivities an extra boost by issuing a proclamation designating Sept. 16 as “Open Science Day” in the Emerald City.

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How satellites and AI work together to monitor the planet

Geospatial data analysis promises to revolutionize the way agriculture, urban planning and disaster relief is done — and thanks to a variety of projects that make use of artificial intelligence, Microsoft and Seattle’s Allen Institute for AI are part of that revolution.

The Allen Institute for AI, also known as AI2, recently rolled out Satlas, a new software platform for exploring global geospatial data generated from satellite imagery. Meanwhile, Microsoft’s AI for Good Lab is working with public and private institutions in Colombia on Project Guacamaya, which uses AI tools to monitor and understand conditions in the Amazon Rainforest.

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Experiment blazes a trail for growing stem cells in space

Space: The final frontier … for stem cells? Seattle’s Allen Institute for Cell Science says cells from its collection are going into space for the first time on a private mission to the International Space Station.

The Allen Cell Collection’s assortment of human induced pluripotent stem cells, or IPSCs, will be the focus for one of more than 20 experiments being sent into orbit on a flight organized by Texas-based Axiom Space.

Former NASA astronaut Peggy Whitson will command the Ax-2 mission — Axiom’s second trip to the space station — and her crewmates will include Tennessee business executive John Shoffner as well as Saudi astronauts Ali Alqarni and Rayyanah Barnawi.

SpaceX’s Falcon 9 rocket will loft the crew into orbit in a SpaceX Crew Dragon capsule for what’s expected to be a weeklong stay on the station. Liftoff is set for May 21 at 5:37 p.m. ET (2:37 p.m. PT) at NASA’s Kennedy Space Center in Florida. The fare for each rider on last year’s Ax-1 mission was around $55 million, and although the ticket price for Ax-2 hasn’t been announced, it’s probably in a similar range.

The stem-cell study is part of a series of NASA-funded experiments led by researchers at Cedars-Sinai Medical Center in Los Angeles. This experiment is expected to break new ground when it comes to growing IPSCs in space and modifying the cells’ DNA for therapeutic purposes.

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Are you illiterate about AI? Test your AI IQ

Can artificial intelligence write its own programs? Is there AI in your TV remote control? Researchers at Seattle’s Allen Institute for Artificial Intelligence say that knowing the right answers to such questions is an essential part of being literate in our tech-driven society — and that most of us would get a failing grade.

A national survey, involving 1,547 adult Americans who were given a 20-question quiz about AI’s capabilities, found that only 16% of the test takers scored a passing grade of better than 60% on the quiz.

“The majority of Americans are AI illiterate,” Nicole DeCario and Oren Etzioni report today in a posting to PNW.ai, an information service provided by the institute, also known as AI2. Etzioni is AI2’s CEO, while DeCario leads AI2’s special projects team.

What’s your AI IQ? Take AI2’s quiz

The researchers acknowledge that the extent of AI illiteracy shouldn’t be surprising. “AI is not part of our schools’ curricula, and the main source of information about it today, according to our survey, is YouTube and social media,” they write.

However, they argue that a basic understanding of how AI works is “critical for informing everyday decisions, adopting appropriate economic policies and maintaining national security.”

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AI makes customer service bots sound more like humans

Earlier this year, Seattle-based WellSaid Labs helped create an AI disk jockey with a voice that sounds like it’s coming from a flesh-and-blood DJ. Now WellSaid’s lifelike voice bots could be coming to a customer-service line near you.

California-based Five9 says it will incorporate WellSaid’s voice synthesis technology into its Virtual Voiceover menu of synthetic voices suitable for self-service contact centers. The new capabilities will be provided to users of the Five9 Inference Studio 7 platform at no additional cost, with wide availability planned in early 2022.

WellSaid Labs, a three-year-old startup fostered at the Allen Institute for Artificial Intelligence’s AI2 Incubator, takes advantage of artificial intelligence to produce natural-sounding synthetic voices like the ones that Five9 will give its Intelligent Virtual Agents, or IVAs.

“In our experience, the more lifelike an IVA can sound, the better the reception it will receive from the customer who is speaking with it,” Callan Schebella, Five9’s executive vice president for product management, said today in a news release. “We’re continually looking for the latest and greatest technologies to enhance the Studio platform, and we are excited to partner with WellSaid to bring this new innovation to our customers.”

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This AI has the upbeat sound of a DJ down pat

As he turns from a Foo Fighters tune to the Smashing Pumpkins, Andy sounds just like your typical alternative-rock DJ — but his tag line is positively inhuman.

“Ever feel like your day just needs a shot of pick-me-up? Well, that’s what we’re here for — to help turn that frown upside down and crank the dial to 11,” he says. “Yes, I may be a robot, but I still love to rock.”

The robot reference isn’t just a nod to his canned DJ cliches: In a sense, Andy really is a robot — as in ANDY, or Artificial Neural Disk JockeY. And thanks to Seattle-based WellSaid Labs and Super Hi-Fi, an AI-centric production company in Los Angeles, ANDY could soon be coming to a streaming music service near you.

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Startup’s AI software tackles stage fright

If you’re intimidated by the prospect of giving a speech, going through a job interview or doing a wedding toast, a Seattle startup called Yoodli might have just the thing: an AI-enabled software platform that analyzes your delivery and gives you tips for improvement — in a non-judgmental way.

Today the venture is coming out of stealth mode, opening up the waitlist for early access to their beta product and announcing a $1 million pre-seed funding round from Seattle’s Allen Institute for Artificial Intelligence and Madrona Venture Group.

Yoodli is a spinout from the incubator program at the institute, also known as AI2. Two of the founders — Varun Puri and Esha Joshi — are AI2 entrepreneurs-in-residence. The third founder is Ehsan Hoque, co-director of the Rochester Human Computer Interaction Lab at the University of Rochester. All three are drawing upon their personal experience as they take the leap into the startup world.

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Scientists unveil ‘wiring diagram’ for a tiny bit of brain

Neuroscientists from Seattle’s Allen Institute and other research institutions have wrapped up a five-year, multimillion-dollar project with the release of a high-resolution 3-D map showing the connections between 200,000 cells in a clump of mouse brain about as big as a grain of sand.

The data collection, which is now publicly available online, was developed as part of the Machine Intelligence From Cortical Networks program, or MICrONS for short. MICrONS was funded in 2016 with $100 million in federal grants to the Allen Institute and its partners from the Intelligence Advanced Research Projects Activity, the U.S. intelligence community’s equivalent of the Pentagon’s DARPA think tank.

MICrONS is meant to clear the way for reverse-engineering the structure of the brain to help computer scientists develop more human-like machine learning systems, but the database is likely to benefit biomedical researchers as well.

“We’re basically treating the brain circuit as a computer, and we asked three questions: What does it do? How is it wired up? What is the program?” R. Clay Reid, senior investigator at the Allen Institute and one of MICrONS’ lead scientists, said today in a news release. “Experiments were done to literally see the neurons’ activity, to watch them compute.”