Creating a virtual brain may sound like a science-fiction nightmare, but for neuroscientists in Japan and at Seattle’s Allen Institute, it’s a big step toward a long-held dream.
They say their mouse-cortex simulation, run on one of the world’s fastest supercomputers, could eventually open the way to understanding the mechanisms behind maladies such as Alzheimer’s disease and epilepsy — and perhaps unraveling the mysteries of consciousness.
“This shows the door is open,” Allen Institute investigator Anton Arkhipov said today in a news release. “It’s a technical milestone giving us confidence that much larger models are not only possible, but achievable with precision and scale.”
Arkhipov and his colleagues describe the project in a research paper being presented this week in St. Louis during the SC25 conference on high-performance computing. The simulation models the activity of a whole mouse cortex, encompassing nearly 10 million neurons connected by 26 billion synapses.
To create the simulation, researchers fed data from the Allen Cell Types Database and the Allen Connectivity Atlas into Supercomputer Fugaku, a computing cluster developed by Fujitsu and Japan’s RIKEN Center for Computational Science. Fugaku is capable of executing more than 400 quadrillion operations per second, or 400 petaflops.
The massive data set was translated into a 3-D model using the Allen Institute’s Brain Modeling ToolKit. A simulation program called Neulite brought the data to life as virtual neurons that interact with each other like living brain cells.
Scientists ran the program in different scenarios, including an experiment that used the full-scale Fugaku configuration to model the entire mouse cortex.
