Allen Institute maps out ‘org chart’ for brain

Allen Institute researchers
Researchers Hongkui Zeng, Julie Harris and Hannah Choi check out a brain connectivity image at the Allen Institute for Brain Science. (Allen Institute Photo)

Researchers at Seattle’s Allen Institute say a new and improved map of the mouse brain reveals not only how different regions are connected, but how those connections are ordered in a hierarchical way.

They add that the mapping techniques behind their study, which was published today by the journal Nature, could shed light on how diseases like Alzheimer’s, Parkinson’s or schizophrenia tangle up connections in the human brain.

The map produced by the study is technically known as a medium-scale “connectome.” It’s been variously compared to a wiring diagram, organizational chart or subway map for the brain. An initial version of the map was published five years ago — and at the time, it was hailed as a landmark for brain science.

Like that earlier version of the Allen Mouse Brain Connectivity Atlas, the newly published map was created by injecting glow-in-the-dark viruses into the brains of mice, and then tracking how brain impulses lit up different types of brain cells.

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By Alan Boyle

Mastermind of Cosmic Log, contributor to GeekWire and Universe Today, author of "The Case for Pluto: How a Little Planet Made a Big Difference," past president of the Council for the Advancement of Science Writing.

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