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Movie-watching mice pose a neurological mystery

Jerome Lecoq
The Allen Institute’s Jerome Lecoq, one of the lead authors of a mouse-brain study, works on one of the 2-photon microscopes that was used to record neural activity in more than 200 mice. (Allen Institute Photo)

For years, neuroscientists have been monitoring the brain activity of mice as they looked at a wide range of images — including the film-noir classic “Touch of Evil” — in hopes of discovering deep insights about the workings of the visual system. Now they’ve come upon a plot twist worthy of director Orson Welles himself.

The latest results, reported today in the journal Nature Neuroscience by researchers at Seattle’s Allen Institute for Brain Science and at the University of Washington, suggest that more than 90% of the neurons in the visual cortex don’t work the way scientists thought.

“We thought that there are simple principles according to which these neurons process visual information, and those principles are all in the textbooks,” Christof Koch, the brain institute’s chief scientist and president, said in a news release. ”But now that we can survey tens of thousands of cells at once, we get a more subtle — and much more complicated picture.”

Not that there’s anything wrong with that.

“To me, that’s the business. In some sense, that’s the exciting thing,” Michael Buice, an associate investigator at the Allen Institute and one of the study’s lead authors, told GeekWire. “We’re in a more interesting place than we thought.”

Get the full story on GeekWire.

By Alan Boyle

Mastermind of Cosmic Log, contributing editor at GeekWire, author of "The Case for Pluto: How a Little Planet Made a Big Difference," president of the Council for the Advancement of Science Writing. Check out "About Alan Boyle" for more fun facts.

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