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Allen Frontiers Group awards $10M for neuroimmunology

The Paul G. Allen Frontiers Group, a division of the Seattle-based Allen Institute, is launching a research center in New York to focus on interactions between the nervous system and the immune system.

The Allen Discovery Center for Neuroimmune Interactions, headquartered at the Icahn School of Medicine at Mount Sinai, will receive $10 million over the course of four years from the Paul G. Allen Family Foundation, with a total potential for $20 million over eight years.

The award is the result of an open call for research proposals exploring fundamental questions at the intersection of neuroscience and immunology. It’s the latest open-science initiative celebrating the legacy of Microsoft co-founder Paul Allen, who died five years ago at the age of 65 from complications of non-Hodgkin’s lymphoma.

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Co-CEOs take the helm at KinectAir digital travel service

Retired Air Force Col. Katie Buss and tech entrepreneur Ben Howard have taken the helm as co-CEOs of Vancouver, Wash.-based KinectAir, which provides a digital platform for booking on-demand private air travel.

Buss previously served as KinectAir’s chief operating officer. Howard, who co-founded the privately held company in 2019, was chief technology officer before his promotion. Fellow co-founder Jonathan Evans is leaving the CEO post but continues to serve as KinectAir’s board chair.

The new management arrangement aims to facilitate scaled-up operations at KinectAir. As co-CEO for aviation, Buss will focus on the aviation sector and industry relationships as well as safety and regulatory issues. As co-CEO for technology, Howard will advance the company’s AI-powered app and operating system to connect vetted flight operators and passengers nationwide.

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Helijet plans to buy electric air taxis for B.C. flights

Vancouver, B.C.-based Helijet International has placed firm orders with Vermont-based Beta Technologies for a fleet of electric-powered vertical-takeoff-and-landing aircraft, or eVTOLs.

The aircraft, popularly known as flying taxis, are currently slated to undergo commercial regulatory certification in 2026 and would be available for commercial service shortly thereafter, Helijet said in a news release.

Beta Technologies’ Alia eVTOLs are built to carry a pilot and up to five passengers. The aircraft would be integrated into Helijet’s existing helicopter flight network, focusing on scheduled service between Vancouver, Victoria and Nanaimo. They’d also be used for emergency response, air ambulance and organ transfer services in British Columbia’s Lower Mainland, plus charter services for rural and remote communities.

The Alia orders were announced today at Helijet’s Victoria Harbour Heliport, with B.C. Premier David Eby in attendance.

“We are committed to introducing and integrating zero-emission, vertical-lift technologies and related ground/building infrastructure in the communities we serve, and look forward to transforming our current heliport infrastructure to meet future urban air mobility vertiport standards,” said Danny Sitnam, Helijet’s president and CEO.

Eby said Helijet’s move into the eVTOL market is consistent with British Columbia’s commitment to promoting sustainable aviation technology and infrastructure development.

“This provincial government recognizes the potential of advanced air mobility to decarbonize the aviation sector, improve regional connectivity, improve emergency response times and introduce new manufacturing opportunities in our province,” Eby said.

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Zeno wins $7.5M contract for underwater nuclear power

Zeno Power says it’s been awarded a $7.5 million contract from the Department of Defense to build and demonstrate a radioisotope power system that can provide distributed power on the seabed.

The program, funded through the Pentagon’s Operational Energy Innovation Office and the Office of Naval Research, calls for the demonstration to take place by 2025.

Zeno maintains offices in Seattle as well as Washington, D.C., and one of its partners in the program is Jeff Bezos’ Blue Origin space venture, which is headquartered in Kent, Wash.

The objective of the program — known as Distributed Energy Provided Throughout the Seas, or DEPTHS — is to develop decentralized nodes for energy generation and distribution on the seabed. Such a system could open the way for long-endurance seafloor sensor systems and charging stations for autonomous undersea vehicles.

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Blue Origin’s chief architect lifts the veil on moon startup

Gary Lai’s resume features his status as chief architect and pioneer spaceflier at Jeff Bezos’ Blue Origin space venture — but when he received a Pathfinder Award this weekend at Seattle’s Museum of Flight, the veteran engineer highlighted a lesser-known job, as co-founder and chief technology officer of a moon-centric startup that’s still in stealth mode.

“We aim to be the first company that harvests natural resources from the moon to use here on Earth,” Lai told an audience of about 400 banquet-goers on Oct. 28. “We’re building a completely novel approach to extract those resources, efficiently, cost-effectively and also responsibly. The goal is really to create a sustainable in-space economy.”

The Tacoma, Wash.-based startup, called Interlune, has actually been around for about three years — but it’s been shrouded in secrecy long enough that Lai can still be considered a co-founder. Lai said the other founders include Rob Meyerson, who was Blue Origin’s president from 2003 to 2018; and Apollo 17 astronaut Harrison “Jack” Schmitt, a geologist who set foot on the moon in 1972 and served in the U.S. Senate from 1977 to 1983.

Lai noted that Interlune recently received a grant from the National Science Foundation. That $246,000 grant supports efforts to develop a system that could sort out moon dirt by particle size.

Neither Lai nor Meyerson, who was in the audience cheering him on, was willing to say much more about Interlune, due to the fact that the venture is still in stealth. But a filing with the Securities and Exchange Commission indicates that the venture raised $1.85 million in seed funding last year from five unnamed investors.

The SEC form also names longtime aerospace industry executive Indra Hornsby as an officer of the company, and lists Estes Park, Colo., as Interlune’s headquarters. However, Hornsby’s LinkedIn page says she’s currently an adviser and a former chief operating officer. Other documents indicate that Tacoma, Meyerson’s home base, has become Interlune’s HQ.

Lai said that he would continue to advise Blue Origin on a part-time basis, focusing on advanced concepts that include the Blue Moon lunar landing system. But going forward, Lai plans to give more attention to what humans will be doing on the moon after they land.

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Jeff Bezos and NASA’s chief share a peek at lunar lander

Jeff Bezos’ Blue Origin space venture and NASA Administrator Bill Nelson today provided a look at coming attractions in the form of a social-media glimpse at Blue Origin’s Blue Moon lunar lander, festooned with a golden feather logo.

In a series of posts to X / Twitter and Instagram, Bezos and Nelson showed off a mockup of the nearly three-story-tall Blue Moon MK1 cargo lander, which is taking shape at Blue Origin’s production facility in Huntsville, Ala.

“MK1’s early missions will pave the way and prove technologies for our MK2 lander for @nasa’s Human Landing System,” Bezos said on Instagram. He also recapped a few technical details — noting that the MK1 is designed to deliver up to 3 tons of cargo to anywhere on the moon’s surface, and that it’ll fit in the 7-meter fairing of Blue Origin’s New Glenn rocket. New Glenn is slated for its first launch next year.

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Zeno Power tests a new type of nuclear heat source

Zeno Power says it has successfully completed its first demonstration of a new type of radioisotope heat source that could be used to generate off-grid power in settings ranging from the bottom of the ocean to the surface of the moon.

The demonstration — performed at Pacific Northwest National Laboratory in Richland, Wash. — took advantage of the energy provided by the radioactive decay of strontium-90. Zeno said its tests confirmed that the company’s technology can increase the specific power of its heat source compared with previously available strontium-90 heat sources.

Zeno uses radioisotope heat sources as the building blocks for its power-generating systems, which are designed to convert constant thermal energy into electricity. Strontium-90, which is typically created as a byproduct of nuclear fission, is an abundant fuel for such systems — but existing strontium-based power systems tend to be bulky. Zeno’s design could generate more power with less bulk, opening the way for a wider range of applications.

The work at PNNL involved radioactive and non-radioactive activities, including chemical processing and fuel fabrication, materials handling and heat source characterization. The test data will support further development of heat sources.

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AI-savvy writers do a reality check on techno-optimism

How will “The Techno-Optimist Manifesto,” venture capitalist Marc Andreessen’s paean to economic growth and artificial intelligence, play to a wider audience? The reviews are in from two award-winning writers who are familiar with the impact of generative AI on creative professions.

“I think it’s mostly nonsense,” science-fiction writer Ted Chiang said Oct. 19 at the GeekWire Summit in Seattle.

Chiang, a longtime Seattle-area resident, is best-known as the author of “Story of Your Life,” the novella that was adapted for the Oscar-nominated 2016 movie “Arrival.” But he’s also won acclaim as a commentator on AI’s effects for The New Yorker and other publications. Last month, Time magazine included Chiang among the 100 most influential people in AI.

The other writer on the SIFF Cinema stage was Eric Heisserer, the screenwriter who turned Chiang’s story into the script for “Arrival.” Heisserer witnessed the debate over generative AI and the future of work up close as a member of the negotiating committee for the Writers Guild of America during its recent strike against Hollywood studios.

Both Chiang and Heisserer say AI is too often unjustly portrayed as a high-tech panacea. That claim came through loud and clear in Andreessen’s manifesto, which called AI a “universal problem solver.”

“Technology can solve certain problems, but I think the biggest problems that we face are not problems that have technological solutions,” Chiang said in response. “Climate change probably does not have a technological solution. Wealth inequality does not have a technological solution. Most of these are problems of political will. … And so Marc Andreessen’s manifesto is a prime example of ignoring all of these other realities.”

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Brain-cell atlases point to paths for future research

In a tour de force for neuroscience, teams of researchers have published a voluminous set of brain-cell atlases for humans and other primates.

The atlases are detailed in 21 research papers appearing in ScienceScience Advances and Science Translational Medicine — and could point scientists toward new strategies for addressing mental conditions ranging from Alzheimer’s disease and schizophrenia to epilepsy and ADHD.

“We need to understand the specifics of the human brain if we hope to understand human diseases,” Ed Lein, a senior investigator at Seattle’s Allen Institute, said in comments provided via video.

“Most of disease research tries to create a replicate or a model of a human disease in a species that doesn’t get that disease,” Lein explained. “But if we want to understand why we get it, and what the consequences are, and how one should treat it, we need to have a deep understanding of the human brain itself.”

The studies in the package released today are part of the National Institutes of Health’s BRAIN Initiative Cell Census Network, or BICCN, a program that was launched in 2017. The Allen Institute for Brain Science has played a major role in sharing data produced by the program.

One study analyzed more than a million cells taken from 42 regions of the brain. Another study drew high-quality samples from more than 100 brain regions. Yet another study focused on samples from prenatal brain tissue. The collective efforts of the research teams characterized more than 3,000 human brain cell types.

The researchers didn’t just examine the brain cells themselves. They also ran them through DNA analysis to learn which genes appeared to be linked to the cells’ functions and dysfunctions.

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Coast Guard delivers more debris from Titan sub wreck

The U.S. Coast Guard says it has recovered and transferred the remaining evidence and debris from OceanGate’s Titan submersible to a U.S. port for cataloging and analysis — more than three months after the deep-sea implosion that killed the sub’s five crew members in the North Atlantic.

In an update issued today, the Coast Guard said the transfer was made on Oct. 4. “Additional presumed human remains were carefully recovered from within Titan’s debris and transported for analysis by U.S. medical professionals,” it said.

OceanGate was a startup headquartered in Everett, Wash. — and the company’s founder and CEO, Stockton Rush, was among the casualties. In August, OceanGate said a new CEO with tech industry experience, Gordon Gardiner, would lead the company through the investigation and the closure of operations.